Electroslag remelting (ESR) has been widely applied as an important technology to produce ingots for special steels and alloys because of its remarkably advantages, such as the process can purify the prepared ingots by effectively eliminating the impurity sulfur and the large inclusions. However, as one of the most important parameters of ESR, the effect of melting rate on the purity of ingot is still controversial. For this purpose, the macro- and micro-structure and nonmetallic inclusion characteristics at different positions of GH4169G ingots produced by industrial-scale argon protected electroslag remelting (PESR) technology with 2 remelting rates were comparatively investigated by means of OM, SEM, EDS and EPMA. The results indicate that a proper high melting rate is beneficial to shorten the local solidification time of ingot, reduce the secondary dendrite arm spacing and refine dendrite structure, but has little effect on the distribution of Nb, Ti and other elements along the radial direction in macro-scale. Besides, the melting rate has little effect on the inclusion types of GH4169G ingot, which are mainly oxides, fluorides and nitrides. The inclusions in the ingot are usually double or three layers with oxide as the core, nitride as the secondary outer layer and carbide as the outermost layer. The influence of the melting rate on the movement of inclusions in the remelting process was simulated via the so called MeltFlow-ESR software. It was found that the increase of melting rate was conducive to the movement of inclusions to the ingot surface, thereby the thickness of the inclusion enriched area on the surface of the ingot and the number of inclusions in the ingot could be reduced. In addition, the increase of melting rate can shorten the time of inclusion precipitation and reduce the size of inclusions.