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材料研究学报  2012, Vol. 26 Issue (6): 572-576    
  研究论文 本期目录 | 过刊浏览 |
医用多孔TiO2/HA/TiO2复合涂层的制备和性能
张静娴1, 洪秋虹1, 孙学通2, 张新平2
1.暨南大学化学系 广州 510632
2.华南理工大学材料科学与工程学院 广州 510640
Preparation and Properties of Porous TiO2/HA/TiO2 Composite Coating
ZHANG Jingxian1, HONG Qiuhong1, SUN Xuetong2, ZHANG Xinping2
1.Department of Chemistry, Jinan University, Guangzhou 510632
2.School of Materials Science and Engineering, South China University of Technology, Guangzhou 510640
引用本文:

张静娴 洪秋虹 孙学通 张新平. 医用多孔TiO2/HA/TiO2复合涂层的制备和性能[J]. 材料研究学报, 2012, 26(6): 572-576.
ZHANG Jingxian HONG Qiuhong SUN Xuetong Xinping. Preparation and Properties of Porous TiO2/HA/TiO2 Composite Coating[J]. Chinese Journal of Materials Research, 2012, 26(6): 572-576.

全文: PDF(981 KB)  
摘要: 

采用溶胶--凝胶法在多孔NiTi合金表面制备出多孔TiO2/羟基磷灰石(HA)/TiO2复合涂层, 研究了复合涂层的性能。结果表明:与未经过涂层处理的样品相比, 涂有复合涂层的样品在模拟体液(SBF)溶液中Ni离子的释放率大大降低;复合涂层具有比单一涂层更好的生物活性, 在快速钙化溶液(FCS)中能诱导磷灰石快速生长;多孔NiTi合金的特殊孔道结构为药物的可控释放创造了条件, 使药物释放呈现缓慢可控的规律。

关键词 无机非金属材料多孔NiTi合金溶胶--凝胶法复合涂层药物释放    
Abstract

A porous TiO2 /HA/TiO2 composite coating was prepared on the surface of a porous NiTi alloy by mixed sol method. The release rates of Ni ion of the porous NiTi alloy of different porosity ratios in the composite coatings in a simulated body fluid decrease markedly compared with the uncoated alloys. The composite coatings have better biological activity than that of a single–layer coating and then can induce the growth of apatite quickly. The release characteristics of gentamicin sulfate loaded on the
porous NiTi alloy was also investigated. The results show that the porous NiTi alloy can control the release of drugs by means of the special pore structure, and the drugs show a slow and controlled release pattern.

Key wordsinorganic non–metallic materials    porous NiTi alloy    sol–gel method    composite coating    drugs release
收稿日期: 2012-05-10     
ZTFLH:  TB321  
基金资助:

国家自然科学基金50871039、51001050和广东省自然科学基金10151064101000017资助项目。

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