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材料研究学报  2011, Vol. 25 Issue (2): 135-140    
  研究论文 本期目录 | 过刊浏览 |
壳聚糖固载环糊精--海藻酸钠凝胶球的制备和载药性能
洪春双, 李明春, 辛梅华, 谢峰, 毛扬帆
华侨大学材料科学与工程学院福建省高校功能材料重点实验室 厦门 361021
Synthesis and Drug Release Performance of Chitosan Immobilized Cyclodextrin–Sodium Alginate
HONG Chunshuang, LI Mingchun, XIN Meihua, XIE Feng, MAO Yangfan
College of Material Science and Engineering, Huaqiao University, The Key Laboratory for Functional Materials of Fujian Higher Education, Xiamen 361021
引用本文:

洪春双 李明春 辛梅华 谢峰 毛扬帆. 壳聚糖固载环糊精--海藻酸钠凝胶球的制备和载药性能[J]. 材料研究学报, 2011, 25(2): 135-140.
, , , , . Synthesis and Drug Release Performance of Chitosan Immobilized Cyclodextrin–Sodium Alginate[J]. Chin J Mater Res, 2011, 25(2): 135-140.

全文: PDF(935 KB)  
摘要: 使用环糊精和对甲苯磺酰氯制备单--(6--O--对甲苯磺酰基)--β--环糊精, 将其与壳聚糖反应后得到可溶于醋酸溶液的壳聚糖固载环糊精, 使用一步法与海藻酸钠形成凝胶球(ALg--CDS)。用FTIR、UV、TG--DTA、XRD和SEM对产物进行表征, 研究了凝胶球在模拟肠液和胃液中的溶胀行为及载药释放性能。结果表明,ALg--CDS凝胶球在肠液中的溶胀率比在胃液中的大; 对酮洛芬的吸附过程符合Lagergren二级动力方程, 且ALg--CDS凝胶球的载药量(4.19 mg/mg)优于ALg--CS(3.76 mg/mg), ALg--CDS凝胶球比ALg--CS有更好的缓释效果, 环糊精的引入提高了载药量和缓释性能。
关键词 有机高分子材料壳聚糖环糊精海藻酸钠凝胶球载药性能    
Abstract:An acid soluble chitosan immobilized cyclodextrin (CDS) was synthesized by grafting p–toluenesulfonyl–β–cyclodextrin onto chitosan, then formed gel with alginate sodium (ALg–CDS). The structure of ALg–CDS was characterized by FTIR, UV, TG–DTA, XRD and SEM, and using ketoprofen as a modal drug, the release behavior from ALg–CDS and ALg–CS in simulated intestinal fluid and simulated gastric fluid had been investigated. The results show that the swelling ratio of ALg–CDS in simulated intestinal fluid was higher than that in simulated gastric fluid. ALg–CDS (4.19 mg/mg) has better drug–loading capacity than that of ALg–CS (3.76 mg/mg), and represented more stable release of the entrapped ketoprofen in simulated intestinal fluid because of cyclodextrin, the adsorption data was in line with the Lagergren second–order kinetics.
Key wordsorganic polymer materials, chitosan, &beta    &ndash    cyclodextrin, alginate sodium, hydrogel, controlled release
收稿日期: 2010-11-12     
ZTFLH: 

O 636

 
基金资助:

福建省重点科技项目2009H0030、福建省自然科学基金E0810019和2009J01029及科技部科技人员服务企业基金资助项目。

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