Pre-alloyed powders of Ti-47Al-2Cr-2Nb-0.15B (%, atom fraction) were prepared by an electrode induction melting gas atomization process, and powder metallurgy (PM) γ-TiAl alloys were prepared by hot isostatic press (HIP). Pre-alloyed powders of γ-TiAl were characterized. A comparison study was made between vacuum degassed and not degassed for the pre-alloyed powders and the PM alloys were subjected to tensile and rupture life test at different temperatures. Infrared spectrum analysis showed that the powders would absorb H₂O when exposed in air. By getting rid of the absorbed H₂O and O₂ through a carefully designed vacuum degassing pre-treatment, the numbers of voids in the prepared PM γ-TiAl alloys decreased obviously, correspondingly the rupture life, as well as the consistency of room temperature tensile elongation, was also improved. In order to find out the influence of container materials on the microstructure and mechanical properties of the PM γ-TiAl alloys, two different container materials (CP-Ti and mild steel) were adopted. Experimental results showed that a lot of obvious voids appeared in the reaction zone due to severe reaction diffusion between the mild steel container and the PM γ-TiAl alloys when HIPed at 1260^oC. The shielding effect of the mild steel container was stronger than that of the CP-Ti container, thus the densification shrinkage process of the CP-Ti canned PM γ-TiAl alloys would be more fully completed when HIPed at 1230^oC compared with that of the mild steel canned PM γ-TiAl alloys, and thereby both of the yield and tensile strength were both improved. The γ-TiAl alloys prepared by powder metallurgy route present more uniform microstructure, finer grain and better properties compared with the casting alloys. Furthermore, the PM γ-TiAl alloys had no texture which was very common for the casting alloys.