|
|
|
| Hydrophilicity Degradability and Cell Toxicity of Ti-P Polylactide Paterial Synthesized by Titanium (IV) Complex as Catalyst |
Chengbo HU( ) |
| Chongqing Key Laboratory of Environmental Materials & Remediation Technologies, Chongqing University of Arts and Sciences, Chongqing 402160 |
|
Cite this article:
Chengbo HU. Hydrophilicity Degradability and Cell Toxicity of Ti-P Polylactide Paterial Synthesized by Titanium (IV) Complex as Catalyst. Chinese Journal of Materials Research, 2014, 28(5): 395-400.
|
|
|
Abstract Ti-P polylactide was synthesized by ring-opening polymerization (ROP) of D, L-lactide with bis-(alkoxy-imine-phenoxy) titanium (IV) complex as catalyst. The physico-chemical properties of the Ti-P material were investigated by measurements of contact angle, water absorption rate and degradability, while its biocompatibility to MC3T3-E1 cells, such as the proliferation, adhesion and spreading performance of murine preosteoblastic cells (MC3T3-E1) was also investigated. The results show that the hydrophilicity of Ti-P polylactide is weaker than Sn-P polylactide, inversely, its anti-hydrolysis ability is stronger. In contact with the Ti-P polylactide material, the MC3T3-E1 cells showed excellent activity in proliferation, adhesion and spreading. The rudimental Ti(IV) complex in the Ti-P polylactide exihibits non-toxicity to MC3T3-E1 cell and does not hamper the growth of MC3T3-E1 cells on the surface of the Ti-P polylactide material.
|
|
Received: 25 August 2013
|
| Fund: *Supported by Natural Science Foundation Project of the Chongqing Science and Technology Commission in China No.cstc2013jcyjA50022 and Scientific Research Project of Chongqing University of Arts and Sciences in China No.Z2013CH07. |
| 1 | Z. Zhong, P. J. Dijkstra, J. Feijen,Controlled and stereoselective polymerization of lactide: kinetics, selectivity, and microstructures, Journal of American Chemical Society, 125(37), 11291(2003) | | 2 | H. R. Kricheldorf, I. Kreiser-Saunders, C. Boettcherl,Polylactones: 31. Sn(II) octoate-initiated polymerization of L-Lactide: a mechanistic study, Polymer, 36(6), 1253(1995) | | 3 | C. P. Radano, G. L. Baker, M. R. Smith,Stereoselective polymerization of a racemic monomer with a racemic catalyst: direct preparation of the polylactic acid stereocomplex from racemic lactide, Journal of American Chemical Society, 122(7), 1552(2000) | | 4 | A. John, V. Katiyar, K. Pang, M. M. Shaikh, H. Nanavati, P. Ghosh,Ni(II) and Cu(II) complexes of phenoxy-ketimine ligands: synthesis, structures and their utility in bulk ring-opening polymerization (ROP) of L-Lactide, Polyhedron, 26(15), 4033(2007) | | 5 | A. Amgoune, C. M. Thomas, T. Roisnel,Ring-opening polymerization of lactide with group 3 metal complexes supported by dianionic alkoxy-amino-bisphenolate ligand: combining high activity, productivity, andselectivity, Chemistry-A European Journal, 12(1), 169(2005) | | 6 | N. Nomura, R. Ishii, Y. Yamamoto, T. Kondo,Stereoselective ring-opening polymeization of a racemic Lactide by using achiral salen- and homosalen-aluminum complexes, Chemistry-A European Journal, 13(16), 4433(2007) | | 7 | D. J. Darensbourg, O. Karroonnirun,Stereoselective ring-opening polymerization of rac-Lactides catalyzed by chiral and achiral aluminum Half-Salen complexes, Organometallics, 29(21), 5627(2010) | | 8 | H. Ma, J. Okuda,Kinetic and Mechanism of L-lactide polymerization by rare earth metal silylamido complexes: effect of alcohol addition, Macromolecules, 38(7), 2665(2005) | | 9 | M. H. Chisholm,Catalytic formation of cyclic-esters and depsipeptides and chemical amplification by complexation with sodium ions, Journal of Organometallic Chemistry, 693(5), 808(2008) | | 10 | C. Hu, Y. Wang, H. Xiang, Y. Fu, C. Fu, J. Sun, Y. Xiang, C. Ruan, X. Li,Synthesis and characterization of Ti(Tbse)2 and its application as a catalyst for ROP of rac-Lactide, Polymer International, 61(10), 1564(2012) | | 11 | C. Hu, Y. Fu, H. Xiang, Y.Fu, J.Sun, M.Deng, X. Xiang,The Novel [(dME)2(HIM)P]2Ti (IV) Complex: synthesize, characterization and its utility in ROP of D, L-Lactide, Polymer Bulletin, 69(5), 511(2012) | | 12 | HU Chengbo,FU Ya, XIANG Hongzhao, SUN Jiaoxia, RUAN Changshun, LI Xiang, XIANG Yan, PENG Qin, WANG Yuanliang, ROP of D, L-Lactide catalyzed by bis(alkoxy-imine-phenoxy) titanium(IV) complex: kinetic and mechanism, Acta Chimica Sinica, 69(21), 2574(2011) | | 12 | (胡承波, 傅 亚, 向鸿照, 孙娇霞, 阮长顺, 李 香, 向 燕, 彭 琴, 王远亮, 双(烷氧-亚胺芳氧)基钛(IV)配合物催化D, L-丙交酯开环聚合、动力学及机理, 69(21), 2574(2011)) | | 13 | HU Chengbo, XU Qiang, WANG Yuanliang, ZHENG Shiyuan, Microstructure analysis of Ti-P polylactide synthesized by titanium(IV) complex as catalyst, 21(4), 18(2013) | | 13 | (胡承波, 徐 强, 王远亮, 郑士远, 钛(IV)配合物催化合成TI-P聚乳酸材料微观结构分析, 21(4), 18(2013)) | | 14 | S. Kaihara, S. Matsumura, A. G. Mikos, J. P. Fisher,Synthesis of poly(L-lactide) and polyglycolide by Ring-opening polymerization, Nature protocols, 2(11), 2767(2007) | | 15 | K. B. Vartanian, S. J. Kirkpatrick, S. R. Hanson, M. T. Hinds,Endothelial cell cytoskeletal alignment independent of fluid shear stress on micropatterned surfaces, Biochemical and Biophysical Research Communications, 371(4), 787(2008) | | 16 | CAI Qing,BEI Jianzhong, WANG Shenguo, WANG Changyong, FAN Ming, LIU Shuang, ZHAO Qiang, Study on the biocompatibility and degradation behavior of polyl( l-lactide-co- glycolide) in vitro and in vivo, Journal of Functional Polymers, 13(3), 249(2000) | | 16 | (蔡 晴, 贝建中, 王身国, 王常勇, 范 明, 刘 爽, 赵 强, 乙交酯/丙交酯共聚物的体内外降解行为及生物相容性研究, 功能高分子学报, 13(3), 249(2000)) | | 17 | X. Wu, N. Wang,Synthesis, characterization, biodegradation, and drug delivery application of biodegradable lactic/glycolic acid polymers. Part II: Biodegradation, Journal of Biomaterials Science-Polymer Edition, 12(1), 21(2001) |
|
| No Suggested Reading articles found! |
|
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
| |
Shared |
|
|
|
|
| |
Discussed |
|
|
|
|
