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| Drug Release Behavior of Porous Hydroxyapatite Microspheres |
| XU Wei1, YAO Aihua1,2, AI Fanrong1,3, WANG Deping1,2, HUANG Wenhai1,2 |
1.School of Materials Science and Engineering, Tongji University, Shanghai 200092
2.Key Laboratory of Advanced Civil Engineering Materials, Ministry of Education, Tongji University, Shanghai 200092
3.College of Mechanical and Electrical Engineering, Nanchang University, Nanchang 330031 |
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Cite this article:
XU Wei YAO Aihua AI Fanrong WANG Deping HUANG Wenhai. Drug Release Behavior of Porous Hydroxyapatite Microspheres. Chin J Mater Res, 2011, 25(4): 439-443.
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Abstract Porous hydroxyapatite (HA) microspheres were prepared by a situ Li-Ca-B glass conversion process. The phase composition, pore structure and morphology were characterized by XRD, SEM and BET. The results show that the resultant microspheres possess good internal porous structure. The release behavior of lysozyme as a model drug was investigated in the present work. The results show that lysozyme molecules mainly are absorbed on the external surface of the porous HA when concentration of lysozyme is low. A large amount of lysozyme is loaded in the pores of the microspheres when high concentration of lysozyme is used, which effectively prolonged the drug release. The loading behavior was successfully observed in the 1.0 mg/ml lysozyme solution and the drug can still be released after 800 hours.
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Received: 30 March 2011
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| Fund: Supported by Key Project on Basic Reseach of Shanghai No. 08JC1419200 and Program for Young Excellent Talents in Tongji University. |
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