Finite Element Analysis for Hemodynamic Behavior of Bioprosthetic Heart Valves

doi:10.11901/1005.3093.2017.109

Chinese Journal of Materials Research

2018, Vol. 32

Issue (1): 51-57 DOI: 10.11901/1005.3093.2017.109

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Finite Element Analysis for Hemodynamic Behavior of Bioprosthetic Heart Valves

Chen LIU¹, Lijian YANG¹(

), Xing ZHANG²

1 Shenyang University of Technology, Shenyang 110870, China
2 Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China

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Chen LIU, Lijian YANG, Xing ZHANG. Finite Element Analysis for Hemodynamic Behavior of Bioprosthetic Heart Valves. Chinese Journal of Materials Research, 2018, 32(1): 51-57.

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Abstract

The hemodynamic property in physiological saline solution of bioprosthetic heart valve was measured under the physiological considition using a pulse duplicator, accordingly, based on the above measured data, the stress and strain distribution on heart valve leaflets was analized by means of finite element analysis (FEA) at the microscopic level over a cardiac cycle, so that to assess the relationships between the structure and mechanical properties of the bioprosthetic heart valve. The measured parameters of the bioprosthetic heart valve (Edwards #2625) are as follows: the mean transvalvular pressure ~10.8 mmHg, the effective opening area ~2.0 cm² and the regurgitant fraction ~8.4%, which all meet the requirements of the ISO-5840 standard; The FE simulation results show that the maximum principal stresse was 425 kPa during the systolic phase, the major stress concentration was found on the belly and the suture edge of the leaflet, which underwent severe bending deformation. The maximum principal stresse was 1.46 MPa during the diastolic phase, and the major stress concentration was found on the two sides of the suture of the leaflet; The valvular open areas at different time points were close to those measured during experimental tests, indicating the relibility of the FEA method. Thus, the combination of the simulation test and and the finite element simulation calculation may be considered as an efficient and relible stratigy to evaluate the relationships between the structure and mechanical properties of bioprosthetic heat valve.

Key words: organic polymer materials bioprosthetic heart valves hemodynamic property stress distribution finite element analysis pulsatile flow test

Received: 31 January 2017

ZTFLH:

R318.1

Fund: Supported by National Natural Science Foundation of China (No. 31300788)

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https://www.cjmr.org/EN/10.11901/1005.3093.2017.109 OR https://www.cjmr.org/EN/Y2018/V32/I1/51

Table 1 Design parameters for the bioprosthetic heart valve

Fig.1 Geometric model of the bioprosthetic heart valve: (a) front view, (b) top view

Table 2 Material properties for the bioprosthetic heart valve

Fig.2 Boundary settings for the bioprosthetic heart valve

Fig.3 Time-dependent blood pressure of the left ventricular and aortic pressure curve(a), and time-dependent transvalvular blood flow (b) for a bioprothetic heart valve in a cardiac cycle

Table 3 Key parameter values from experimental tests and from ISO-5840 standard

Fig.4 Loading time-dependent curve of transvalvular pressure

Fig.5 Maximum principal stress distribution among the heart valve leaflets during the cardiac cycle (MPa)

Fig.6 Displacement distribution among the heart valve leaflets during the cardiac cycle (mm)

Fig.7 Geometric orifice areas from experimental tests (a-c) and FE simulation (d-f) at different time points: (a, d) 0.05 s and (b, e) 0.20 s during the systole period, and (c, f) 0.50 s during the diastole period

[1]	Lin W D, Askar S B.Present situation and the development of heart valve disease in adults[J]. Hosp. Pract., 2016, 22(4): 499(林伟德, 艾斯卡尔沙比提. 成人心脏瓣膜病的治疗现状与发展[J]. 岭南心血管病杂志, 2016, 22(4): 499)
[2]	Liang J S, Yin G L.Research progress of anticoagulant after artificial heart valve replacement[J]. Mil. Med. J. S. Chin., 2013, 27(3): 208(梁江水, 殷桂林. 人工心脏瓣膜置换术后抗凝研究进展[J]. 华南国防医学杂志, 2013, 27(3): 208)
[3]	Lis G J, Masztafiak J C, Kwiatek W M, et al.Distribution of selected elements in calcific human aortic valvesstudied by microscopy combined with SR-μXRF: Influence of lipids on progression of calcification[J]. Micron, 2014, 67: 141
[4]	Butcher J T, Simmons C A, Warnock J N.Mechanobiology of the Aortic Heart Valve[J]. J. Heart Valve. Dis., 2008, 17(1): 62
[5]	Yuan Q, Wang X W, Zhang C R.Geometry design theory and finite element analysis of bioprosthetic heart valve[J]. Chin. J. Tissue Eng. Res., 2007, 18(11): 3480(袁泉, 王晓伟, 张承瑞. 生物瓣膜几何设计理论及其有限元分析[J]. 中国组织工程研究与临床康复, 2007, 18(11): 3480)
[6]	Ma X J, Du Y W, Zhang L N.Fluid solid interaction analysis of bioprosthetic heart valve[J]. Chin. J. Med. Instrumentation, 2014, 38(5): 325(马雪洁, 杜亚伟, 张黎楠. 人工生物瓣膜流固耦合分析[J].中国医疗器械杂志, 2014, 38(5): 325)
[7]	Weinberg E J, Schoen F J, Mofrad M R K, et al. A computational model of aging and calcification in the aortic heart valve[J]. Plos One, 2009, 4(6): e5950
[8]	Annerel S, Claessens T, Degroote J, et al.Validation of a numerical FSI simulation of an aortic BMHV by in vitro PIV experiments[J]. Med. Eng. Phys. Med., 2014, 36(8): 1014
[9]	Piatti F, Sturla F, Marom G, et al.Hemodynamic and thrombogenic analysis of a trileaflet polymeric valve using a fluid-structure interaction approach[J]. J. Biomech., 2015, 48(13): 3650
[10]	Smuts A N, Blaine D C, Scheffer C, et al.Application of finite element analysis to the design of tissue leaflets for a percutaneous aortic valve[J]. J. Mech. Behav. Biomed. Mater, 2011, 4(1): 85
[11]	Kim H, Chandran K B, Sacks M S, et al.An experimentally derived stress resultant shell model for heart valve dynamic simulations[J]. Ann. Biomed. Eng., 2016, 35(1): 30
[12]	Li J, Luo X Y, Kuang Z B.A nonlinear anisotropic model for porcine aortic heart valves[J]. J. Biomech., 2001, 34(10): 1279
[13]	Marom G, Haj-Ali R, Rosenfeld M, et al.A fluid-structure interaction model of the aortic valve with coaptation and compliant aortic root[J].Med. Biol. Eng. Comput., 2012, 50(2): 173
[14]	Astorino M, Gerbeau J F, Pantz O, et al.Fluid-structure interaction and multi-body contact: Application to the aortic valves[J]. Comput. Method. Appl. M., 2009, 198(45): 3603
[15]	Halevi R, Hamdan A, Marom G, et al.Progressive aortic valve calcification: Three-dimensional visualization and biomechanical analysis[J]. J. Biomech., 2015, 48(3): 489
[16]	Cheng A, Nguyen T C, Malinowski, et al. Undersized mitral annuloplasty inhibits left ventricular basal wall thickening but does not affect equatorial wall cardiac strains-meeting discussion[J]. J. Heart Valve. Dis., 2007, 16(4): 349
[17]	Bouchareb R, Boulanger M C, Fournier, et al. Mechanical strain induces the production of spheroid mineralized microparticles in the aortic valve through a RhoA/ROCK-dependent mechanism[J]. J. Mol. Cell Cardiol., 2014, 67: 49
[18]	Mohammadi H, Bahramian F, Wan W.Advanced modeling strategy for the analysis of heart valve leaflet tissue mechanics using high-order finite element method[J]. Med. Eng. Phys., 2009, 31(9): 1110
[19]	Kim H, Lu J, Sacks M S.Dynamic simulation of bioprosthetic heart valves using a stress resultant shell model[J]. Ann. Biomed. Eng., 2007, 36(2): 262
[20]	Kamenskya D, Hsub M, Schillingerc D.An immersogeometric variational framework for fluid-structure interaction: Application to bioprosthetic heart valves[J]. Comput. Method. Appl. M., 2015, 284: 1005
[21]	Pibarot P, Dumesnil J G, Cartier P C.Patient-prosthesis mismatch can be predicted at the time of operation[J]. Ann. Thorac. Surg., 2001, 71(5): 26
[22]	Saikrishnan N, Kumar G, Sawaya F J.A review of diagnostic modalities and hemodynamics[J].Circulation, 2014, 129(2): 244
[23]	Gabbay S, McQueen D M, Yellin E L. In vitro hydrodynamic comparison of mitral valve prostheses at high flow rates[J]. J. Thorac. Cardiov. Sur., 1978, 76(6): 771
[24]	Gillinov A M, Blackstone E H, Rodriguez L L.Prosthesis-patient size: Measurement and clinical implications[J]. J. Thorac. Cardiov. Sur., 2003, 126(2): 313

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