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| Analysis of Cell Behaviors in Chitosan Sponges with Hierarchical Open Pores |
| ZHAO Mingyan1,2, LI Lihua1,2, ZHOU Changren1,2, LI Xian1,2 |
1.Department of Material Science and Engineering, Jinan University, Guangzhou 510632
2.Engineering Research Center of Artificial Organs and Materials, Jinan University, Guangzhou 510632 |
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Cite this article:
ZHAO Mingyan LI Lihua ZHOU Changren LI Xian. Analysis of Cell Behaviors in Chitosan Sponges with Hierarchical Open Pores. Chin J Mater Res, 2011, 25(3): 243-248.
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Abstract A novel hierarchically porous chitosan (HPCS) sponge with large open pores and interconnected small pores on the surface was fabricated with ice particles as poroen. The honeycomb patterned porous composite scaffolds (HPCS) was obtained by immersing the sponges into poly (L-lactic acid) chloroform solution. A comparison of the morphology, mechanical properties and cell compatibility with the three different sponges were made. Results show that honeycomb patterned porous structure is visible in the THCP sponges, wherein interconnected micro pores embedded in larger open pores and formed uniform network. Hierarchically porous structure is visible in the HPCS sponges. The compressive strength of the THCP sponges dramatically increased, cell viability and cell proliferation index (PI) are higher than that of the CS and HPCS sponges. The topographical design of chitosan scaffolds remedied the traditional freeze-drying technique, improved cell biocompatibility and elongated the design of topological structure into the three dimension area.
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Received: 03 March 2011
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| Fund: Supported by National Natural Science Foundation of China No.30900307, the Ph.D. Programs Foundation of Ministry of Education of China No.200805590001, and Natural Science Fund of Guangdong Province No.9451063201002964. |
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