|
|
|
| Cytocompatibility of PCL/PVP Composite Nanofibrous Scaffolds |
Shuqiong LIU1,Xiufeng XIAO2,**( ) |
1. Ecology and Resource Engineering, Wuyi University, Wuyishan 354300
2. College of Chemistry and Chemical Engineering, Fujian Normal University, Fuzhou 350007 |
|
Cite this article:
Shuqiong LIU,Xiufeng XIAO. Cytocompatibility of PCL/PVP Composite Nanofibrous Scaffolds. Chinese Journal of Materials Research, 2014, 28(10): 769-774.
|
|
|
Abstract By using polycarpolactone (PCL) and polyvinylpyrrolidone (PVP) as raw materials, a series of nanofibrous scaffolds were fabricated by thermally induced phase separation in a dioxane/water system. The effect of aging temperature, PVP content and different ratios of dioxane to water on the morphology of nanofibrous scaffolds was investigated. The effect of PVP content on the biological activity and hydrophilic performance of the prepared nanofibrous scaffolds were also examined. The results show that aging process played a crucial role in forming the unique nanofibrous structure. The solvent system and the PVP content affect the nanofibrous structure, peculiarly; the nanofibrous structure would disappear gradually with the increasing PVP content. The result of the water absorption shows that the hydrophilic performance of the nanofibrous stent increases with the increasing PVP content. Furthermore, the test of biological activity shows that there exists crystallite carbonate hydroxyapatite in the scaffolds, indicating that the PCL/PVP nanofiberous scaffolds have a good biological activity, and which may much rapidly facilitate the forming of crystallite carbonate hydroxyapatite rather than the merely PCL ones.
|
|
Received: 25 April 2014
|
| Fund: *Supported by National Nature Science Foundation of China No.30970887 and Young Teachers Foundation of Wuyi University No.xq201102. |
| 1 | Sangsanoh P, Waleetorncheepsawat S, Suwantong O, Wutticharoenmongkol P, Weeranantanapan O, Chuenjitbuntaworn B, Cheepsunthorn P, Pavasant P, Supaphol P, In vitro biocompatibility of Schwann cells on surfaces of biocompatible polymeric electrospun fibrous and solution-cast film scaffolds, Biomacromolecules, 8, 1587(2007) | | 2 | Aihemat, Wang ZB, Zhu L, Application of biodegradable polycaprolactone in medicine, Biomedical Engineering Foreign Medical Sciences, 28(1), 19(2005) | | 3 | Shor L, Güceri S, Wen X, Gandhi M, Sun W, Fabrication of three-dimensional polycaprolactone/hydroxyapatite tissue scaffolds and osteoblast-scaffold interactions in vitro, Biomaterials, 28(35), 5291(2007) | | 4 | Baker SC, Rohman G, Southgate J, Cameron NR, The relationship between the mechanical properties and cell behaviour on PLGA and PCL scaffolds for bladder tissue engineering, Biomaterials, 30(7), 1321(2009) | | 5 | Ma T F, Shi T J, Properties, Synthesis and applications of PVP, Applied Chemical Industry, 31(3), 16(2002) | | 5 | (马婷芳, 史铁钧, 聚乙烯吡咯烷酮的性能、合成及应用, 应用化工, 31(3), 16(2002)) | | 6 | Chen X B, A?Study?of?Preparation?of?PCL/PVP?Blend?Films?and Their?Properties, Journal?of?Wuyi?University (Natural?Science?Edition), 25(2), 43(2011) | | 6 | (陈向标,PCL/PVP共混膜的制备与性能研究, 五邑大学学报(自然科学版), 25(2), 43(2011)) | | 7 | Liu S Q, Xiao X F, Liu R F, Lin Y H, Zhong Z Y, Jiao J J, Fabrication of poly(L-lactic acid) nanofibrous scaffolds by thermally induced phase separation, chemical Journal of Chinese universities, 32(2), 372(2011)) | | 7 | (刘淑琼, 肖秀峰, 刘榕芳, 林月红, 钟章裕, 焦简金, 热致相分离制备聚乳酸纳米纤维支架, 高等学校化学学报, 32(2), 372(2011)) | | 8 | Liu S Q, Xiao X F, Liu R F, Zhong Z Y, Jiao J J, Fabrication of polycaprolactone nanofibrous scaffolds by thermally induced phase separation, Chemical Industry and Engineering Progress, 30(5), 1059(2011) | | 8 | (刘淑琼, 肖秀峰, 刘榕芳, 钟章裕, 焦简金, 相分离制备聚己内酯纳米纤维支架的工艺探讨, 化工进展, 30(5), 1059(2011)) | | 9 | Song C X, Wang P Y, Sun H H, Y J, Cui X M, Shi R W, The in vivo degradation, adsorption and excrction of poly(ε-caprolactone), J Biomed Eng, 17(1), 25(2000) | | 9 | (宋存先, 王彭延, 孙洪范, 施化莲, 杨菁, 崔秀敏, 史瑞文, 聚己内酯在体内的降解、吸收和排泄, 生物医学工程学杂志, 17(1), 25(2000)) | | 10 | Cuneyt TA, Synthesis of biomimetic Ca hydroxyapatite powders at 37℃ in synthetic body fluids, Biomaterials, 21, 1429(2000) | | 11 | Woo KM, Jun JH, Chen VJ, Seo JY, Baek JH, Ryoo HM, Kim GS, Somerman MJ, Ma PX, Nano-fibrous scaffolding promotes osteoblast differentiation and biomineralization, Biomaterials, 28(2), 335(2007) | | 12 | Hua FJ, Park TG, Lee DS, A facile preparation of highly interconnected macroporous PLGA scafolds by liquid liquid phase separation of a PLGA-dioxane-water ternary system, Polymer, 44(6), 1911(2003) | | 13 | He LM, Zhang YQ, Zeng X, Quan DP, Liao SS, Zeng YS, Lu J, Ramakrishna S, Fabrication and characterization of poly(L-lactic acid) 3D nanofibrous scaffolds with controlled architecture by liquid-liquid phase separation from a ternary polymer-solvent system, Polymer, 50(16), 4128(2009) | | 14 | Xu F, Wang D W, Chen S F, Wang W H, Zhou C H, Cui F Z, Zhang B, Preliminary study for vascular tissue engineering by electrospinning PLLA/PVP nanofiber films, Journal of Southeast University (Medical Science Edition), 30(3), 391(2011) | | 14 | (徐飞, 王大伟, 陈双峰, 王伟华, 周长辉, 崔福斋, 张彬, 电纺PLLA/PVP纳米纤维膜材料用于血管组织工程的前期研究, 东南大学学报(医学版), 30(3), 391(2011)) | | 15 | Yang F, Wolke J G C, Jansen J A, Biomimetic calcium phosphate coating on electrospun poly (ε-caprolactone) scaffolds for bone tissue engineering, Chemical Engineering Journal, 137(1), 154(2008) | | 16 | Yamaguchi, Tokuchi K, Fukuzaki H, Koyama Y, Takakuda K, Monma H, Tanaka J, Preparation and microstructure analysis of chitosan/hydroxyapatite nanocomposites, Journal of Biomedical Materials Research, 55(1), 20(2001) | | 17 | Mo L R, Li Y B, Lv G Y, Study on nano-hydroxyapatite crystals synthesized under different conditions, Chemical Research and Application, 18(3), 230(2006) | | 17 | (莫利蓉, 李玉宝, 吕国玉, 不同条件下合成的纳米羟基磷灰石晶体的性能研究, 化学研究与应用, 18(3), 230(2006)) | | 18 | Liu Y, Zhong K N, Hu W Y, Influences of Synthetic Conditions on the Characteristics of Hydroxyl-Apatite Synthesised by Sol-gel Method, Materials Science & Engineering, 15(1), 63(1997) | | 18 | (刘羽, 钟康年, 胡文云, 溶胶-凝胶法合成条件与羟基磷灰石特征的关系, 材料科学与工程, 15(1), 63(1997)) | | 19 | Huang Z L, Wang D W, Liu Y, Zhang Y, Xu H Y, FT-IR Investigation on Crystal Chemistry of Various CO32- -Substituted Hydroxyapatite Solid Solution, Chinese Journal of Inorganic Chemistry, 18(5), 469(2002) | | 19 | (黄志良, 王大伟, 刘羽, 张昱, 胥焕岩,不同类型的CO32-替换羟基磷灰石固溶体晶体化学FT-IR研究, 无机化学学报, 18(5), 469(2002)) | | 20 | Han J M, Li Y B, Liang X J, Comparison of compositional and structural characterizations of synthetic nano-hydroxyapatite and mineral phase from human teet, Jouranl of Functional Materials, 36(7), 1069(2005) | | 20 | (韩纪梅, 李玉宝, 梁新杰, 纳米羟基磷灰石与牙无机质的比较研究, 功能材料, 36(7), 1069(2005)) |
|
| No Suggested Reading articles found! |
|
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
| |
Shared |
|
|
|
|
| |
Discussed |
|
|
|
|
