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材料研究学报  2012, Vol. 26 Issue (5): 449-455    
  研究论文 本期目录 | 过刊浏览 |
镁合金表面的仿生修饰及抑菌性能的研究
田金环1, 焦延鹏1, 周长忍1, 党向利2, 丁珊1, 李立华1, 李红1
1.暨南大学理工学院材料科学与工程系 广州 510630
2.浙江省亚热带作物研究所 温州 325005
Surface Biomimetic Modification and Antibacterial Activity of AZ91 Magnesium Alloy
TIAN Jinhuan, JIAO Yanpeng, ZHOU Changren, DANG Xiangli,  DING Shan, LI Lihua, LI Hong
1.Department of Material Science and Engineering, College of Science and Engineering, Jinan University, Guangzhou 510630
2.Zhejiang Institute of Subtropical Crops, Wenzhou 325005
引用本文:

田金环 焦延鹏 周长忍 党向利 丁珊 李立华 李红. 镁合金表面的仿生修饰及抑菌性能的研究[J]. 材料研究学报, 2012, 26(5): 449-455.
TIAN Jinhuan JIAO Yanpeng ZHOU Changren DANG Xiangli DING Shan LI Lihua LI Hong. Surface Biomimetic Modification and Antibacterial Activity of AZ91 Magnesium Alloy[J]. Chinese Journal of Materials Research, 2012, 26(5): 449-455.

全文: PDF(1335 KB)  
摘要: 

用2, 3--环氧丙基三甲基氯化铵对壳聚糖进行改性, 合成了两种不同取代度(DS:29%, 48%)的壳聚糖季铵盐, 通过FTIR、HNMR表征以证实其分子结构。用仿生共沉积法, 在模拟体液中添加两种不同取代度的壳聚糖季铵盐, 在镁合金AZ91表面修饰了一层薄的仿生涂层。SEM和XRD对涂层分析表明: 经仿生修饰后的镁合金表面为含有钙磷盐/壳聚糖季铵盐的复合涂层, 涂层晶体构型不同。抑菌实验结果表明:与含有钙磷盐/壳聚糖的复合涂层样品相比, 含有钙磷盐/壳聚糖季铵盐的复合涂层对金黄色葡萄球菌具有明显的抑菌作用;比浊法测定显示:对金黄色葡萄球菌作用6 h, 四种含有不同量的壳聚糖季铵盐样品均具有较好的抑菌效果, 抑菌率为90%以上;作用24 h的结果表明, 模拟体液中添加较低浓度的壳聚糖季铵盐制备的样品抑菌效果较好, 抑菌率为98%。

关键词 材料表面与界面季铵盐涂层抑菌性能    
Abstract

The quaternary ammonium salts of chitosan (HACC) were synthesized with two different degrees of substitution (DS: 29%, 48%) of quaternary ammonium by reacting chitosan with glycidyl trimethylammonium chloride. Characterization of HACC was analyzed with IR spectra and HNMR spectroscopy. A biomimetic coating was codeposited on the surface of AZ91 magnesium alloy by adding HACC of two DS into simulated body fluid (SBF). The CaP/HACC coatings were analyzed by scanning electron microscopy (SEM) and X ray diffraction (XRD). The coatings have different crystal types. The results of antibacterial assays show that the CaP/HACC coatings have more antimicrobial activity to Staphylococcus aureus than CaP/CS coatings. The absorbances at the 6th hour show that the bacterial inhibition rate of four samples exceeds 90%. The absorbances at the 24th hour show that the samples obtained by adding the HACC of lower concentration into simulated body fluid have better antimicrobial effect and their bacterial inhibition rate reaches 98%.

Key wordssurface and interface in the materials    quaternary ammonium of salt    coating    antimicrobial activity
收稿日期: 2012-06-18     
ZTFLH:  O482  
基金资助:

国家自然科学基金81171459和中央高校基本科研业务费专项资金项目21613125和21612317, 广州市珠江科技新星项目(2011)资助。

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