Preparation and Properties of Nanocomposite Hydrogel with Dopamine Modification

doi:10.11901/1005.3093.2023.342

Chinese Journal of Materials Research

2024, Vol. 38

Issue (4): 269-278 DOI: 10.11901/1005.3093.2023.342

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Preparation and Properties of Nanocomposite Hydrogel with Dopamine Modification

WANG Zhongnan(

), GUO Hui, MU Yueshan

School of Mechanical, Electronic and Control Engineering, Beijing Jiaotong University, Beijing 100044, China

Cite this article:

WANG Zhongnan, GUO Hui, MU Yueshan. Preparation and Properties of Nanocomposite Hydrogel with Dopamine Modification. Chinese Journal of Materials Research, 2024, 38(4): 269-278.

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Abstract

Zwitterionic hydrogel is one of the most promising cartilage repair and replacement materials with good biocompatibility and anti-bacteria adhesion properties. However, there is a certain gap involving in mechanical properties compared to natural cartilage, which greatly limits its practical application. Herein, the nano-hydroxyapatite was modified with dopamine by acid, and alkali conditions respectively to obtain a nanoparticle-modified composite hydrogel. It is found that an oxide film could form on the surface of nano hydroxyapatite modified by dopamine, and the benzene ring in the modified nano particles is combined to form a covalent bond with the zwitterionic hydrogel polymer chain. Meanwhile, dopamine improves the dispersity of nano-hydroxyapatite by acidic condition, thereby enhancing the thermal stability of zwitterionic hydrogel (decomposing until 323^oC), as well as its network structure strength (energy storage modulus of 2.7 MPa) and internal friction capacity (loss factor of 0.041). Moreover, the compressive strength of acid nanocomposite hydrogel arrives at 11.66 MPa, which is 32 times higher than that of pure PSBMA zwitterionic hydrogel. Thus, the structural characteristics and mechanical properties of acid nanocomposite hydrogels are similar to those of natural cartilage, which provides a significant reference for the design and preparation of bionic materials.

Key words: polymer material nanocomposite hydrogel mechanical properties dopamine modification nano hydroxyapatite

Received: 12 July 2023

ZTFLH:

TQ174

Fund: Talent Fund of Beijing Jiaotong University(2022XKRC009);National Natural Science Foundation of China(51905296)

Corresponding Authors: WANG Zhongnan, Tel: 18845616596, E-mail: zhn.wang@bjtu.edu.cn

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	WANG Zhongnan
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https://www.cjmr.org/EN/10.11901/1005.3093.2023.342 OR https://www.cjmr.org/EN/Y2024/V38/I4/269

Fig.1 D@H modification effect (a) infrared spectrum results, (b) raman spectrum results, (c) XRD spectrum results and (d) powder diagram of modified nanoparticles after drying

Fig.2 Changes in the surface color of hydrogel and the color of the surface standing in the air (a), changes in the color of the hydrogel standing in the air after swelling (b), microstructure of the hydrogel (c) and the infrared spectrum of the hydrogel (d)

Fig.3 Diagram of composition structure of hydrogel (a) and diagram of synthesis mechanism (b) of nanocomposite hydrogel

Fig.4 Basic physical and chemical properties of hydrogel (a) weight loss rate versus temperature curve, (b) weight loss rate curve, (c) swelling rate and (d) freeze drying water content

Fig.5 Storage modulus G′ and dissipation modulus G″ of hydrogel with different additives versus angular velocity ω (a), the storage modulus G′ and dissipation modulus G″ of nanocomposite hydrogels with different mass ratios of DA to HA vary with angular velocity ω (b), stress relaxation test results of hydrogels with different additives (c), stress relaxation test results of nanocomposite hydrogels with different DA/HA mass ratios (d), loss factor tan of hydrogels with different additives δ And normalized relaxation modulus G (e), loss factor tan of hydrogels with different mass ratio of DA/HA δ Normalized relaxation modulus G (f) and TD@H-GE adhesion of nanocomposite hydrogels (g)

Fig.6 Compression fracture test results of hydrogels with different additives (a) and nanocomposite hydrogels with different mass ratios of DA/HA (b)

Fig.7 Compression cycle test results of hydrogel (a) PSBMA hydrogel (b) GE-PSBMA comixed hydrogel (c) HA-GE nanocomposite hydrogel (d) TD@H-GE nanocomposite hydrogel (e) D@H-GE nanocomposite hydrogel

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