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| Preparation and blood compatibility of polyurethane films blending and grafting with heparin in the same solvent system |
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| 北京理工大学 |
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Cite this article:
. Preparation and blood compatibility of polyurethane films blending and grafting with heparin in the same solvent system. Chin J Mater Res, 2004, 18(3): 251-256.
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Abstract Heparin homogeneously mixed with polyurethane in the co--solvent of tetrahydrofuran
and water through adjusting the ratio of the two solvents. After the film was
prepared with casting method, heparin was homogeneously blended in polyurethane
films. At the same time, through preaction of heparin with 1--(3-dimethyl
aminoprophyl)--3--ethylcarbodimide hydrochloride (DCCI), heparin partly grafted
with the residual of polyurethane and the films containing free and covalent
heparin was obtained using solvent casting. The heparin release rate was
investigated with toluidine blue heparin assay (TBHA). The blood compatibility of
polyurethane films was assessed with thrombin time (TT), prothrombin time (PT) and
activated partial thromboplastin time (APTT). The results indicated that
polyurethane containing heparin showed expected blood compatibility and
polyurethane containing free and covalent heparin had the excellent
bioactivity of free heparin and the long--term blood compatibility of
covalent heparin.
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Received: 19 July 2004
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