Preparation of Ultra-fast Temperature Responsive Nanofibrous Hydrogel and Application in Controllable Drug Release

doi:10.11901/1005.3093.2019.493

Chinese Journal of Materials Research

2020, Vol. 34

Issue (6): 452-458 DOI: 10.11901/1005.3093.2019.493

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Preparation of Ultra-fast Temperature Responsive Nanofibrous Hydrogel and Application in Controllable Drug Release

ZHENG Xie¹^,², ZHA Liusheng¹^,²(

)

1.State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, Shanghai 201620, China
2.College of Materials Science and Engineering, Donghua University, Shanghai 201620, China

Cite this article:

ZHENG Xie, ZHA Liusheng. Preparation of Ultra-fast Temperature Responsive Nanofibrous Hydrogel and Application in Controllable Drug Release. Chinese Journal of Materials Research, 2020, 34(6): 452-458.

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Abstract

The nanofibers were firstly prepared by static electrospinning process using the fiber-forming copolymer synthesized from N-isopropylacrylamide and N-methylol acrylamide, and then they were shortened and dispersed in tert-butanol by high-speed stirring. Finally, the shortened nanofibers were assembled into nanofibrous hydrogel with hierarchical porous structure by the processes of freeze drying and followed heat treatment. The resultant nanofibrous hydrogel in aqueous medium holds excellent stability, compression resilience and remarkable temperature-responsiveness. When the temperature of an aqueous medium changed alternately between 20℃ and 55℃, in which the nanofibrous hydrogel reached its swelling- and deswelling-equilibrium state within 34 s and 45 s respectively, exhibiting ultra-fast temperature responsiveness. In vitro drug release experiment results show that when the temperature of the phosphate buffered solution of pH7.4 is altered alternately between 15^oC and 47^oC the immersed dextran (model drug) loaded nanofibrous hydrogel can controllably release the drug by ''on/off'' mode.

Key words: organic polymer materials temperature responsive nanofibrous hydrogel static electrospinning controllable drug release

Received: 25 October 2019

ZTFLH:

TQ430.50

Fund: National Natural Science Foundation of China(51373030)

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https://www.cjmr.org/EN/10.11901/1005.3093.2019.493 OR https://www.cjmr.org/EN/Y2020/V34/I6/452

Fig.1 ¹H NMR spectrum of PNN (a) and temperature dependence of light transmittance at the wavelength of 500 nm for the PNN aqueous solution of ca.0.1% (mass fraction) concentration (b)

Fig.2 SEM images of PNN nanofibers with different magnification times (a) low magnification, (b) high magnification

Fig. 3 Optical images of temperature responsive nanofibrous hydrogels with various shapes (a), SEM images of temperature responsive nanofibrous hydrogel at various magnification times (b), optical images of temperature responsive nanofibrous hydrogel in water before and after 300 r/min×24 h oscillation (c), optical images of conventional temperature responsive PNIPAM hydrogel before, during and after compression exerted by a blade (d) and optical images of temperature responsive nanofibrous hydrogel before, during and after compression exerted by a blade (e)

Fig.4 Temperature dependent V/V₀ of the nanofibrous hydrogel or the PNIPAM hydrogel (a), time dependent V/V₀ of the nanofibrous hydrogel immersed alternately in the aqueous medium of 20℃ or 55℃ (b) and the V/V₀ of the nanofibrous hydrogel immersed alternately in the aqueous medium of 20℃ or 55℃ for six cycles (c)

Fig.5 Cumulated drug release profiles obtained from FITC-dextran loaded nanofibrous hydrogel and conventional PNIPAM hydrogel in response to alternating change of temperature between 15 and 47℃

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