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Effects of Collagen Assembly Form on Biomimetic Mineralization |
DING Shan1,2,**( ), TANG Minjian3, CHEN Junjie1, ZHOU Changren1,2, LI Lihua1,2, LI Hong1,2 |
1. Department of Material Science and Engineering, Jinan University, Guangzhou 510632, China 2. Engineering Research Center of Artificial Organs and Materials, Ministry of Education, Guangzhou 510632, China 3. Patent Examination Cooperation Center of the Patent Office, SIPO, Guangzhou 510530, China |
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Cite this article:
DING Shan, TANG Minjian, CHEN Junjie, ZHOU Changren, LI Lihua, LI Hong. Effects of Collagen Assembly Form on Biomimetic Mineralization. Chinese Journal of Materials Research, 2016, 30(1): 51-56.
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Abstract To simulate the ordered texture of the collagen in natural bone tissue, membranes of collagen with hierarchically ordered texture were fabricated. The effect of templates made of collagen with and without ordered texture on the biomineralization process of calcium phosphate was comparatively studied in vitro. The morphology and structure of the deposited calcium phosphate on the collagen templates were characterized by using polarizing microscope (POM), scanning electron microscope (SEM), atomic force microscope (AFM) and X-ray diffraction (XRD). The results show that the collagen with hierarchically ordered texture has obvious effect on the biomimetic mineralization process; on which the deposited calcium phosphate is much more orderly and compact either in micro- or in macro scales. This result indicates that the collagen with hierarchically ordered texture is beneficial to the building of biomimetic bone tissues as materials for repair of human bone etc.
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Received: 13 May 2015
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Fund: *Supported by the National Natural Science Foundation of China Nos.31400824 & 31270021 |
About author: **To whom correspondence should be addressed, Tel: (020) 85226663, E-mail: tdingshan@jnu.edu.cn |
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