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材料研究学报  2011, Vol. 25 Issue (2): 193-198    
  研究论文 本期目录 | 过刊浏览 |
AZ31B镁合金表面氟涂层的生物相容性和抗菌性能
李绮1, 刘新杰1, 王泽庆1, 颜廷亭2, 谭丽丽2, 张炳春2, 杨柯2
1.辽宁大学化学学院 沈阳 110036
2.中国科学院金属研究所 沈阳 110016
Biocompatibility and Antibacterial Property of a Fluoride Coating on AZ31B Magnesium Alloy
LI Qi1,  LIU Xinjie1,  WANG Zeqing1,  YAN Tingting2,  TAN Lili2,  ZHANG Bingchun2,  YANG Ke2
1.School of Chemistry, Liaoning University, Shenyang 110036
2.Institute of Metal Research, Chinese Academy of Science, Shengyang 110016
引用本文:

李绮 刘新杰 王泽庆 颜廷亭 谭丽丽 张炳春 杨柯. AZ31B镁合金表面氟涂层的生物相容性和抗菌性能[J]. 材料研究学报, 2011, 25(2): 193-198.
, . Biocompatibility and Antibacterial Property of a Fluoride Coating on AZ31B Magnesium Alloy[J]. Chin J Mater Res, 2011, 25(2): 193-198.

全文: PDF(599 KB)  
摘要: 采用化学转化方法在AZ31B镁合金表面制备氟涂层, 系统研究了氟涂层的表面形貌、体外生物相容性和抗菌性能。结果表明: AZ31B镁合金表面的氟涂层均匀致密;
氟涂层镁合金的溶血率明显降低, 且无细胞毒性, 可满足生物医用材料的要求。同时, 氟涂层镁合金的抗凝血性能与316L不锈钢相当, 并具有显著的抗菌功能。
关键词 材料表面与界面镁合金氟涂层生物相容性抗菌性能    
Abstract:A fluoride coating was prepared on AZ31B magnesium alloy by chemical conversion treatment in order to control the biodegradation rate and further increase the biocompatibility of AZ31B alloy. The surface morphology, in vitro biocompatibility and antibacterial property of the coated alloy were investigated in the study. The result showed that the fluoride coating was compact and presented obvious decrease of the hemolytic rate and non- cytotoxicity, meeting the requirement on biomaterials. The result also showed a better behavior against blood coagulation of the coated AZ31B alloy than that of 316L stainless steel, as well as an  excellent antibacterial ability.
Key wordssurface and interface in the materials    magnesium alloy    fluoride coating    biocompatibility    antibacterial property
收稿日期: 2010-12-20     
ZTFLH: 

R318

 
基金资助:

辽宁省教委自然科学基金2008222,中国科学院知识创新工程重要方向基金KGCX2-YW-207和中科院金属研究所青年人才领域前沿基金O7A7721171资助项目。

1 XU Tao, HUO Chunbao, Magnesium and human health, Guangdong Trace Elements Science, 10(6), 11(2003)

(许涛, 贺春宝, 镁与人体健康, 广东微量元素科学, 10(6), 11(2003))

2 Hideyuki Kuwahara, Yousel A1-Abdulat, Naoko Mazaki, Precipitation of magnesium apatite on pure magnesium surface during immersing in Hanks solution, Materials Transactions, 42, 1317(2001)

3 ZHANG Jin, ZHANG Zonghe, Magnesium alloys and their applications, (Beijing, Chemical Industry Press, 2004) p.211

(张津, 章宗和, 镁合金及应用, (北京, 化学工业出版社, 2004) p.211)

4 SONG Guangling, SONG Shizhe, The corrosion behavior of magnesium in the simulated body fluid, Acta Physico Chimica Sinica, 22(10), 1222(2006)

(宋光铃, 宋诗哲, 镁在人体模拟液中的腐蚀行为, 物理化学学报, 22(10), 1222(2006))

5 G.L.SONG, S.Z.SONG, A Possible Biodegradable magnesium implant material, Advanced Engineering Materials, 9(4), 298(2007)

6 HUANG Jingjing, Study on magnesium-based degradable implant material, PhD Thesis, Shenyang, Institute of Metal Research, Chinese Academy of Sciences, (2008)

(黄晶晶, 可降解镁基植入材料的研究, 博士学位论文, 中国科学院金属研究所, (2008))

7 J.Z.Li, J.G.Huang, Y.W.Tian, C.S.Liu, Corrosion action and passivation mechanism of magnesium alloy in fluoride solution, Transanctions of Nonferrous Metals Society of China, 19, 50(2009)

8 K.Y.Chiu, M.H.Wong, F.T.Cheng, H.C.Man, Characetrization and corrosion studies of fluoride conversion coating on degradable Mg implants, Surface and Coatings Technology, 202(3), 590(2007)

9 S.M.Hamza, G.H.Nancollas, Kinetics of dissolution of magnesium fluoride in aqueous solution, Langmuir, 1, 573(1985)

10 JIANG Wenshu, YIN Guangfu, ZHENG Changqiong, Research on stability of hemocompatibility of DLC Film/Ti6Al4V gradient material using image analysis method, Journal of Biomedical Engineering, 19(4), 642(2002)

(蒋书文, 尹光福, 郑昌琼, 图像分析方法研究DLC膜/Ti6Al4V梯度材料的血液相容性稳定性, 生物医学工程学杂志, 19(4), 642(2002))

11 YU Songting, WENG Mingqing, The basis of biomedical engineering and clinical (Tianjin, Tianjin Science and Technology Press, 1989) p.135

(虞颂庭, 翁铭庆,  生物医学工程的基础与临床  (天津, 天津科学技术出版社, 1989) p.135)

12 Hays, Anterograde coil closure of patent ductus arteriosus using a modified bioptome delivery technique, Catheterization Cardiovasc Diagn, 39(3), 287(1996)

13 Y.Cheng, M.Li, C.Ting, T.Yuan, Preparation of titanium substrate biomaterials by using microarc oxidation and measurement of blood compatibility, Journal of Clinical Rehabilitative Tissue Engineering Research, 11(31), 6315(2007)

14 Lourdes S´anchez, Ver´onica Mart´?nez, M.Rosa Infante, Montserrat Mitjans and M.Pilar Vinardell, Hemolysis and antihemolysis induced by amino acid-based surfactants, Toxicology Letters, 169, 177(2007)

15 Wang ZM, Li L, Zheng BS, Normakhamatov N, Guo SY, Preparation and anticoagulation activity of sodium cellulose sulfate, International Journal of Biological Macromolecules, 41(4), 376(2007)

16 MENG Hao, Biomaterials research interactions with blood, Journal of Biomedical Engineering, 22(6), 1271(2005)

(孟浩, 生物材料与血液相互作用的研究进展, 生物医学工程学杂志, 22(6), 1271(2005))

17 Naorungroj S, Wei HH, Arnold RR, Swift EJ Jr, Walter R, Antibacterial surface properties of fluoridecontaining resin-based sealants, Journal of Dentistry, 38(5), 387(2010)

18 Yoshinari M, Oda Y, Kato T, Okuda K, Influence of surface modifications to titanium on antibacterial activity in vitro, Biomaterials, 22, 2043(2001)

19 Jonathan Lellouche, Edith Kahana, Sivan Elias, Aharon Gedanken and Ehud Banin, Antibiofilm activity of nanosized magnesium fluoride, Biomaterials, 30(30), 5969(2009)
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