Preparation and properties of drug--loaded coating on biodegradable magnesium alloy

Chin J Mater Res

2009, Vol. 23

Issue (3): 300-304 DOI:

论文

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Preparation and properties of drug--loaded coating on biodegradable magnesium alloy

LI Qi¹; TANG Yan^1;2; TAN Lili²; YAN Tingting²; ZHANG Bingch²; YANG Ke²

1.School of Chemistry; Liaoning University; Shenyang 110036
2.Institute of Metal Research; Chinese Academy of Sciences; Shenyang 110016

Cite this article:

LI Qi TANG Yan TAN Lili YAN Tingting ZHANG Bingch YANG Ke. Preparation and properties of drug--loaded coating on biodegradable magnesium alloy. Chin J Mater Res, 2009, 23(3): 300-304.

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Abstract

The sirolimus--releasing PLA--PTMC coating was successfully prepared on the biodegradable AZ31B magnesium alloy coronary stents. The surface morphology, degradability, biocompatibility and drug release characteristic of the coating were also evaluated. The results indicated that PLA--PTMC used as the drug elution coating showed good flexibility with smooth and uniform surface, the degradation period was over one month, and the biocompatibility was excellent. The drug--loaded coating had releasing function of sirolimus and the releasing time was more than one month, which could effectively inhibit the restenosis during the period of intima hypertrophy. The sirolimus--releasing PLA--PTMC coating showed potential to be used as a new type of coronary stent coating.

Key words: organic polymer materials drug--eluting coronary stent drug--loaded coating polylactic acid--polytrimethylene carbonate copolymers

Received: 28 November 2008

ZTFLH:

TB324

Fund:

Supported by Ministry of Education Natural Science Foundation of Liaoning No.2008222 and The Foundations From Chinese Acedamy of Sciences No.KGCX2--YW--207 and No.O7A7721171.

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https://www.cjmr.org/EN/ OR https://www.cjmr.org/EN/Y2009/V23/I3/300

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