Preparation and Performance Characterization of Hydroxyapatite-Barium Titanate as Human Bone Imitating Composite Material

doi:10.11901/1005.3093.2020.474

Chinese Journal of Materials Research

2022, Vol. 36

Issue (1): 40-48 DOI: 10.11901/1005.3093.2020.474

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Preparation and Performance Characterization of Hydroxyapatite-Barium Titanate as Human Bone Imitating Composite Material

ZHANG Changsong(

), WANG Chu, WEI Lizhu, YANG Guanlin

School of Mechanical and Electrical Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China

Cite this article:

ZHANG Changsong, WANG Chu, WEI Lizhu, YANG Guanlin. Preparation and Performance Characterization of Hydroxyapatite-Barium Titanate as Human Bone Imitating Composite Material. Chinese Journal of Materials Research, 2022, 36(1): 40-48.

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Abstract

Hydroxyapatite (HA)-barium titanate (BT) of human bone imitating composite material was prepared by sintering process with HA powder and BT powder as raw material，and then was characterized by XRD, SEM with EDS, synchronous thermal analyzer, universal material testing machine, quasi-static piezoelectric coefficient measuring instrument and dielectric constant measuring instrument. The results show: the partial decomposition of HA and BT resulted in the reaction of the raw materials in the pressed block at certain temperature to produce CaTiO₃, Ca₃(PO₄)₂, TiO₂, BaTi₂O₅ and other phases. The bio-piezoelectric HA-BT composite containing 70% BT sintered at 1200℃ is composed of grains uniform size with good compactness and comprehensive property closed to those of human bone, such as compressive strength (110.215 MPa) and electrical properties (d₃₃=2 pC/N, ε_r=44.6).

Key words: composite biological piezoelectric ceramics bone tissue atmospheric sintering piezoelectric properties

Received: 05 November 2020

ZTFLH:

TB332

Fund: Xi'an Institute of Modern Chemistry Open Cooperative Innovation Fund(SYJJ200304)

About author: ZHANG Changsong, Tel: 15319796585, E-mail: zhangcs@sust.edu.cn

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	Changsong ZHANG
	Chu WANG
	Lizhu WEI
	Guanlin YANG

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https://www.cjmr.org/EN/10.11901/1005.3093.2020.474 OR https://www.cjmr.org/EN/Y2022/V36/I1/40

Fig.1 XRD patterns of HA-BT composite material sintered at 1200℃ for 1 h (a) and double-peak structure in XRD patterns of HA-70BT (b) (●BaTiO₃, ■Ca₁₀(PO₄)₆(OH)₂, ▲CaTiO₃, ◆Ca₃(PO₄)₂, △Ba₄Ti₁₃O₃₀, ○Ba₂TiO₄, ◇TiO₂, □BaTi₂O₅)

Fig.2 SEM images (a~d) and EDS images (e, f) of HA-BT with different BT content sintered at 1200℃ for 1 h (a) HA-10BT; (b) HA-30BT; (c) HA-70BT; (d) HA-90BT; (e, f) EDS spectrum of HA-70 BT composite

Fig.3 Density (a) and compressive strength (b) of HA-BT composite ceramic materials with different BT content after sintering at 1200℃ for 1 h

Fig.4 Electrical parameters of HA-BT composite ceramic materials with different BT content sintered at 1200℃ for 1 h (a) piezoelectric constant (d₃₃); (b) dielectric constant ( $ε r$ ) and dielectric loss ( $t a n ? δ$ )

Fig.5 XRD patterns of HA-70BT sintered at different temperatures (●BaTiO₃, ■Ca₁₀(PO₄)₆(OH)₂, ▲CaTiO₃, ◆Ca₃(PO₄)₂，□BaTi₂O₅，◇TiO₂)

Fig.6 TG (a) -DSC (b) analysis chart of HA-70BT sample

Fig.7 Sintering reaction process of HA-70BT sample

Fig.8 Micro-morphology of HA-70BT sintered at different temperatures (a) 1000℃; (b) 1100℃; (c) 1200℃; (d) 1300℃

Fig.9 Density (a) and compressive strength (b) of HA-70BT sintered at different temperatures

Fig.10 Electrical parameters of HA-70BT sintered at different temperatures (a) Piezoelectric constant (d₃₃); (b) Dielectric constant ( $ε r$ ) and dielectric loss ( $t a n ? δ$ )

1	Ma H S, Feng C, Chang J, et al. 3D-printed bioceramic scaffolds: From bone tissue engineering to tumor therapy [J]. Acta Biomater., 2018, 79: 37
2	Wang Y C, Malcolm D W, Benoit D S W. Controlled and sustained delivery of siRNA/NPs from hydrogels expedites bone fracture healing [J]. Biomaterials, 2017, 139: 127
3	Sui B D, Hu C H, Liu A Q, et al. Stem cell-based bone regeneration in diseased microenvironments: Challenges and solutions [J]. Biomaterials, 2019, 196: 18
4	Zhu Y, Zhang K, Zhao R, et al. Bone regeneration with micro/nano hybrid-structured biphasic calcium phosphate bioceramics at segmental bone defect and the induced immunoregulation of MSCs [J]. Biomaterials, 2017, 147: 133
5	Lai Y X, Cao H J, Wang X L, et al. Porous composite scaffold incorporating osteogenic phytomolecule icariin for promoting skeletal regeneration in challenging osteonecrotic bone in rabbits [J]. Biomaterials, 2018, 153: 1
6	Fukada E, Yasuda I. On the piezoelectric effect of bone [J]. J. Phys. Soc. Jpn., 1957, 12: 1158
7	Itoh S, Nakamura S, Nakamura M, et al. Enhanced bone ingrowth into hydroxyapatite with interconnected by electrical polarization [J]. Biomaterials, 2006, 27: 5572
8	Bagno A, Piovan A, Dettin M, et al. Human osteoblast-like cell adhesion on titanium substrates covalently functionalized with synthetic peptides [J]. Bone, 2007, 40: 693
9	Fukada E. Mechanical deformation and electrical polarization in biological substances [J]. Biorheology, 1968, 5: 199
10	Fukada E, Yasuda I. Piezoelectric effects in collagen [J]. Jpn. J. Appl. Phys., 1964, 3(8): 117
11	Kay M I, Young R A, Posner A S. Crystal structure of hydroxyapatite [J]. Nature, 1964, 204: 1050
12	Jiao H, Zhao K, Bian T R, et al. Hydrothermal synthesis and properties characterization of barium titanate/hydroxyapatite spherical nanocomposite materials [J]. J. Alloys Compd., 2017, 715: 73
13	Lee B T, Kim K H, Youn H C, et al. Functionally gradient and micro-channeled Al₂O₃-(t-ZrO₂)/HAp composites [J]. J Am. Ceram. Soc., 2007, 90: 629
14	Huang S P, Huang B Y, Zhou K C, et al. Effects of coatings on the mechanical properties of carbon fiber reinforced HAP composites [J]. Mater. Lett., 2004, 58: 3582
15	Kumar D, Gittings J P, Turner L G, et al. Polarization of hydroxyapatite: Influence on osteoblast cell proliferation [J]. Acta Biomater., 2010, 6: 1549
16	Bodhak S, Bose S, Bandyopadhyay A. Role of surface charge and wettability on early stage mineralization and bone cell-materials interactions of polarized hydroxyapatite [J]. Acta Biomater., 2009, 5: 2178
17	Teng N C, Nakamura S, Takagi Y, et al. A new approach to enhancement of bone formation by electrically polarized hydroxyapatite [J]. J. Dent. Res., 2001, 80: 1925
18	Park Y J, Hwang K S, Song J E, et al. Growth of calcium phosphate on poling treated ferroelectric BaTiO₃ ceramics [J]. Biomaterials, 2002, 23: 3859
19	Feng J Q, Yuan H P, Zhang X D. Promotion of osteogenesis by a piezoelectric biological ceramic [J]. Biomaterials, 1997, 18: 1531.
20	Tang Y F, Wu C, Wu Z X, et al. Fabrication and in vitro biological properties of piezoelectric bioceramics for bone regeneration [J]. Sci. Rep., 2017, 7: 43360
21	Dubey A K, Anumol E A, Balani K, et al. Multifunctional properties of multistage spark plasma sintered HA-BaTiO₃‐based piezobiocomposites for bone replacement applications [J]. J. Am. Ceram. Soc., 2013, 96: 3753
22	Ozcelik B K, Ergun C, Liu H N. A study on calcium phosphate/barium titanate composites: phase characterization, piezoelectric property, and cytocompatibility [J]. J. Aust. Ceram. Soc., 2020, 56(4): 1197
23	Sharabi M, Mandelberg Y, Benayahu D, et al. A new class of bio-composite materials of unique collagen fibers [J]. J. Mech. Behav. Biomed. Mater., 2014, 36: 71
24	Wu L, Chure M C, Wu K K, et al. Dielectric properties of barium titanate ceramics with different materials powder size [J]. Ceram. Int., 2009, 35: 957
25	Inoue M, Rodriguez A P, Takagi T, et al. Effect of a new titanium coating material (CaTiO₃-aC) prepared by thermal decomposition method on osteoblastic cell response [J]. J. Biomater. Appl., 2010, 24: 657
26	Gu Y W, Loh N H, Khor K A, et al. Spark plasma sintering of hydroxyapatite powders [J]. Biomaterials, 2002, 23: 37
27	Tavangar M, Heidari F, Hayati R, et al. Manufacturing and characterization of mechanical, biological and dielectric properties of hydroxyapatite-barium titanate nanocomposite scaffolds [J]. Ceram. Int., 2020, 46: 9086
28	Vouilloz F J, Castro M S, Vargas G E, et al. Reactivity of BaTiO₃-Ca₁₀(PO₄)₆(OH)₂ phases in composite materials for biomedical applications [J]. Ceram. Int., 2017, 43: 4212
29	Rezwan K, Chen Q Z, Blaker J J, et al. Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering [J]. Biomaterials, 2006, 27: 3413
30	Park J B, Lake R S. Biomaterials. An Introduction [M]. 2nd ed. New York: Plenum Press, 1992: 194

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