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| Biomineralization of type I collagen promoted by an engineered non-collagen protein–derived peptide E8DS |
| WANG Xiumei, WANG Qiong, CHENG Zhenjiang, CUI Fuzhai |
| State Key Laboratory of New Ceramics and Fine Processing, Department of Materials Science $\&$ Engineering, Tsinghua University, Beijing 100084 |
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Cite this article:
WANG Xiumei WANG Qiong CHENG Zhenjiang CUI Fuzhai. Biomineralization of type I collagen promoted by an engineered non-collagen protein–derived peptide E8DS. Chin J Mater Res, 2011, 25(3): 225-230.
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Abstract Peptides with sequence (EEEEEEEEDSpESpSp$EEDR) were synthesized to mimic the biomineralization function of non-collagenous protein over the type I collagens. The results show that the peptide can be bound to Ca$^{2+}$and type I collagen by electrostatic interactions. Moreover, synthetic peptide is conducive to calcium ions binding and promotes the nucleation and formation of minerals on the surface of collagen fibrils. Designed peptides also presented a function of accelerating type I collagen fibrillogenesis and the formation of fibrils bundle or network.
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Received: 23 February 2011
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| Fund: Supported by National Natural Science Foundation of China No.50830102, and National High Technology Research and Development Program No.2011AA030105. |
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