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| Preparation and performance of biodegradable crosslinked PVP materials |
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| 暨南大学 |
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Cite this article:
;. Preparation and performance of biodegradable crosslinked PVP materials. Chin J Mater Res, 2004, 18(5): 511-516.
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Abstract A series of biodegradable crosslinking agents, di--acrylate of polyethylene
glycol and polylactides (PLA--b--PEG--b--PLA) tri--block copolymer,
were synthesized. And then the novel biodegradable crosslinked PVP membrane
materials were prepared by radical polymerization with biodegradable crosslinking
agents and N--vinyl pyrrolidone (NVP) using azoisobutyronitrile (AIBN) as initiator.
The performance of PVP membrane materials was investigated. The results showed that
the intrinsic viscosity of crosslinking agents would be regulated by changing the
ratio of lactide to PEG. The water absorption would decrease, while the contact
angle and the tensile module would increase with increasing the content of
crosslinking agents, but extension at break would increase at first and decrease
at last. The water absorption and the contact angle would increase with increasing
the molecule weights of crosslinking agents. In the degradation process, the
mass--loss rate of the materials showed specific original kinetic in the
initial duration, but it increased dramatically at last.
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Received: 05 November 2004
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1 J.A.Stammen, S.Williams, D.N.Ku, R.E.Guldberg, Biomaterials, 22(8) , 799(2001)
2 A.D.Pozzo, L.Vanini, M.Fagnoni, Carbohydrate Polymers, 42(2) , 201(2000)
3 A.B.Lugo, S.O.Rogero, S.M.Malmonge, Radiation Physics and Chemistry, 63(3～6) , 543(2002)
4 J.X.Wu, Water-Soluble Polymers (Beijing, Chemical Industry Press, 1997) p.586 (吴稼祥,水溶性高分子(北京,化学工业出版社,1997) p.586)
5 CUI Yingde, YI Guobin, LIAO Liewen, Synthesize and Application of Poly(vinyl pyrrolidone) (Beijing, Scinece Press, 2001) (崔英德,易国斌,廖列文,聚乙烯基吡咯烷酮的合成与应用(北京,科学出版社,2001) )
6 M.M.Tunney, S.P.Gorman, Biomaterials, 23(23) , 4601(2002)
7 M.K.Chun, C.S.Cho, H.K.Choi, Journal of Controlled Release, 81(3) , 327(2002)
8 G.Alberto, F.Fernando, B.Paloma, M.Rebuelta, C.Alejandro, Biomaterials, 21,915(2000)
9 ZHANG Run, DENG Zhengxing, LI Lihua, ZHOU Changren, Chinese Journal of Materials Reseach, 17(6) , 665(2003) (张润,邓政兴,李立华,周长忍,材料研究学报,17(6) , 665(2003) )
10 YANG Yanan, LOU Ling, LIANG Qizhi, Chemical Journal of Chinese University, 25(1) , 162(2004) (杨亚楠,娄玲,梁奇志,高等学校化学学报,25(1) ,162(2004) )
11 WANG Guanglin, YANG Zhiming, LIN Wei, BI Jianhong, LI Shengfu, ZHANG Jie, Chinese Journal of Hand Surgery, 18(3) , 134(2002) (王光林,杨志明,林卫,毕建红,李胜富,张杰,中华手外科杂志,18(3) ,134(2002) )
12 CHEN Jianhai, CHEN Kun, M,Shagufla, Acta Pharmaceutica Sinica, 35(8) , 613(2000) (陈建海,陈昆,M,Shagufla,中国药学学报,35(8) ,613(2000) )
13 A.S.Sawhney, P.P.Chandrashekhar, J.A.Hubbell, Macromolecules, 26(4) , 581～587(1993)
14 J.Tessmara, A.Mikosb, A.Gopferich, Biomaterials, 24, 4475(2003)
15 W.N.Chen, W.J.Luo, S.G.Wang, J.Z.Bei, Polymers for Advanced Technologies, 14(3～5) , 245(2003)
16 N.A.Peppas, Advance Drug Delivery Review, 11(1/2) , 137(1993)
17 GAO Yongliang, ZHAO Feng, Chinese Journal of New Drugs, 11(1) , 67(2002) (高永良,赵锋,中国新药杂志,11(1) ,67(2002) )
18 A.Ozkan, M.Yekeler, Journal of Colloid and Interface Science, 261(2) , 476(2003)
19 Watanabe, Junji, Ishihara, Kazuhiko, Science and Technology of Advanced Materials, 4(6) , 539(2003)
20 A.Gopferich, Macromolecules, 30(9) , 2598(1997)
21 F.Burkersroda, R.Gref, A.Gopferich, Biomaterials, 18(24) , 1599(1997)
22 A.T.Metters, K.S.Anseth, C.N.Bowman, Polymer, 41, 3993(2000) |
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