The influence of Fe- and Cu-content on the microstructure and mechanical properties of TC10 alloy bars was investigated by means of scanning electron microscopy, EDS analysis of transmission electron microscopy, and mechanical testing machine. The results indicate that for the as rolled and annealed TC10 Ti-alloys, with the increasing Fe- and Cu-content, their yield strength and tensile strength increase, while the changes in elongation and cross-sectional shrinkage at break are not significant. For the solid solution aged TC10 alloy, Ti is evenly distributed in both β_t and α_p phases, Al is less distributed at grain boundaries, while V, Fe, and Cu elements are more abundant at the grain boundaries in β_t phase. For TC10 alloys with the same Fe- and Cu-content, with the increasing solid solution temperature, their yield strength and tensile strength increase, while the elongation and cross-sectional shrinkage decrease. For TC10 alloys subjected to solid solution treatment at the same temperature, with the increase of Fe and Cu content, their yield strength and tensile strength increase, while the elongation and cross-sectional shrinkage at break decrease. The higher the solid solution temperature, the more significant the influence of alloying elements Fe and Cu on the strength and plasticity of the alloy. Being subjected to solid solution treatment at 900 ^oC, the alloy with 0.65% Fe and 0.65% Cu can achieve superior comprehensive mechanical properties, with yield strength, tensile strength, elongation, and cross-sectional shrinkage at break of 1392 ± 3 MPa, 1435.5 ± 0.5 MPa, (8 ± 1)% and (21.5 ± 1.5)%, respectively.