The effect of sulfate-reducing bacteria (SRB) on the corrosion behavior of N80 steel in SRB containing solution at 20, 37 and 50 ^oC, and for this case the effectiveness of a compound bactericidal corrosion inhibitor in the bactericidal effect and corrosion inhibition performance of N80 steel were comparatively investigated via biological culture technique, weightlessness measurement electrochemical testing, and surface analysis etc. The results showed that the corrosion rate of N80 steel was proportional to the SRB activity at different temperatures. The SRB activity was the highest at 37 ^oC, the polarization resistance R_p of N80 steel was the smallest, and the corrosion rate (0.03553 mm/a) was the largest, which was 1.53 times of that at 20 ^oC and 1.16 times of that at 50 ^oC, thus the corrosion was the most serious. However, after adding the compoundbactericidal corrosion inhibitor, the R_p value of N80 steel at 20 and 37 ^oC were increased significantly, and the corrosion of the steel was effectively inhibitedwith corrosion inhibitionefficiency of 65.45% and 64.79%, respectively. This is mainly due to that the lipophilic group hydroxymethyl of the bactericide tetrahydroxymethyl phosphate sulfate (THPS), as one of the components of the compound bactericide corrosion inhibitor, enters the bacterial cell membrane, changes its protein properties, then resulting in bacteria death; Meanwhile the dimethyl sulfoxide promotes the hydroxymethyl of THPS to enter the bacterial cell membrane and enhances the bactericidal effect. As a signal molecule, D-tyrosine, a bactericidal enhancer, promotes the decomposition of biofilm, destroys the surrounding concentration difference, thus slows down the corrosion. The Chitosan in the corrosion inhibitor combined with Fe²⁺ to produce a protective film to protect the substrate, thereby, reducing the corrosion rate. However, at 50 ^oC, the corrosion inhibition efficiency for N80 steel was only 0.26%, which is due to that the excessive temperature intensifies the movement of corrosion inhibitor molecular, increase in the molecular desorption rate adsorbed on the surface of N80 steel and the dissociates the adsorption film, resulting in a very low corrosion inhibition efficiency.