Preparation and properties of drug elusion coating on coronary stents

Chin J Mater Res

2004, Vol. 18

Issue (4): 380-384 DOI:

Research Articles

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Preparation and properties of drug elusion coating on coronary stents

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中国科学院金属研究所

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;. Preparation and properties of drug elusion coating on coronary stents. Chin J Mater Res, 2004, 18(4): 380-384.

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Abstract Solution polymerisation was employed to prepare the modified polymethacrylate resin as the polymer for coating on coronary stents with drug elusion. Both the polymer and the drug elusion coatings on the stainless steel were prepared by the dipping technology. The composition of copolymer was analyzed by IR and NMR techniques, and the physical property, the biostability and the drug elusion characteristic were also evaluated by Ultro--spectrophotometer, HPLC. The results show that the modified polymethacrylate resin has favorable biostability, and the addition of MAA and BMA provides the polymer with improved physical property, especially the adhesive force between the polymer coating and the stainless steel substrate. The drug elusion coating has paclitaxol releasing function, and its releasing time is more than 15 days. The manufactured paclitaxol--releasing polymethacrylate resin coating can be used as the coronary stent coating.

Key words: polymer materials coronary stent drug elusion coating preparation and property

Received: 31 August 2004

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