Preparation and Antibacterial Function of an Cu-bearing Chitosan Coating on Silicone Rubber Surface

doi:10.11901/1005.3093.2020.047

Chinese Journal of Materials Research

2020, Vol. 34

Issue (8): 575-583 DOI: 10.11901/1005.3093.2020.047

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Preparation and Antibacterial Function of an Cu-bearing Chitosan Coating on Silicone Rubber Surface

WANG Lirong¹, GUAN Hongyu¹(

), CHEN Shanshan²(

), ZHANG Bingchun², YANG Ke²

1 Department of Chemistry, Liaoning University, Shenyang 110036, China
2 Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China

Cite this article:

WANG Lirong, GUAN Hongyu, CHEN Shanshan, ZHANG Bingchun, YANG Ke. Preparation and Antibacterial Function of an Cu-bearing Chitosan Coating on Silicone Rubber Surface. Chinese Journal of Materials Research, 2020, 34(8): 575-583.

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Abstract

In order to solve the infection caused by the indwelling catheter, an anti-infective Cu-bearing chitosan coating was prepared on the silicone rubber surface. But it is difficult to prepare a coating on the surface of silicone rubber due to its biological inertness. Therefore, chemical grafting was used to activate the silicone rubber by the dopamine pretreatment, which provides abundant functional groups on the activated silicone rubber surface. The surface morphology and surface properties of the silicone rubber after surface activation pretreatment were characterized by the active functional groups. Onto which, subsequently, the Cu-bearing chitosan coating could be chemically grafted, and then the surface morphology was compared for the coatings before and after immersion test. The effectiveness of pretreatment process was assessed by the bonding force between the functionalized coating and the silicone rubber. It follows that the abundant functional groups offered by the pretreatment on the activated silicone rubber surface may be beneficial for enhancing the adhesive strength of the functionalized coating to the silicon rubber. Thereby, the Cu-bearing chitosan coating makes the silicone rubber catheter have good antibacterial function.

Key words: surface and interface of material functional coating stepwise chemical grafting silicone rubber catheter bonding ability

Received: 16 February 2020

ZTFLH:

O647

Fund: National Key Research and Development Project(2018YFC1105504);Youth Innovation Promotion Association, Chinese Academy of Sciences(2019194)

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	Lirong WANG
	Hongyu GUAN
	Shanshan CHEN
	Bingchun ZHANG
	Ke YANG

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https://www.cjmr.org/EN/10.11901/1005.3093.2020.047 OR https://www.cjmr.org/EN/Y2020/V34/I8/575

Fig.1 XPS spectra of silicone rubber samples treated by stepwise chemical grafting. (a) full spectrum of samples treated by dopamine; (b) N1s and (c) O1s peak-differenation spectrum of samples treated by dopamine; (d) C1s, (e) N1s and (f) O1s peak-differenation spectrum of samples treated by dopamine and glutaraldehyde coupling

Fig.2 Droplets morphology and water contact angle (a) silicone rubber; (b) dopamine treatment; (c) dopamine-glutaraldehyde cross-linking

Fig.3 XPS spectra of chitosan and copper bearing chitosan coatings. (a), (b), (c) and (d) are respectively full spectrum, C1s, N1s, O1s peaks; (e), (f), (g) and (h) are respectively the XPS peak of Cu2p, C1s, N1s, O1s in the copper bearing chitosan coating

Fig.4 Morphologies of coated samples with and without pre-treatment (a) macroscopic morphology without pre-treatment, (b) microscopic morphology without pre-treatment, (c) microscopic morphology of sample without pre-treatment after 3 d immersion, (d) macroscopic morphology with pre-treatment, (e) microscopic morphology with pre-treatment, (e-1) sectional morphology and thickness of coating, (f) microscopic morphology of samples with pre-treatment after 3 d immersion

Fig.5 Adhesion morphology of S.aureus on the surface of the coated samples (a, b) are the morphologies of S.aureus at low and high magnification on the chitosan coating treated samples, (c, d) are the morphologies of S.aureus at low and high magnification on the copper bearing chitosan coating treated samples

Fig.6 Dopamine polymerization formula (a) self-polymerization of dopamine in aqueous solution^[25] and (b) formation mechanism of polydopamine^[26]

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