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| Synthesis of CS--g--PDLLA Copolymer and {\it in-situ} Fabrication of CS--g--PDLLA/PDLLA Porous Scaffolds in Supercritical Carbon Dioxide |
| LUO Binghong 1,2, CHENG Song 1, ZHONG Cuihong 1, JIAO Yanpeng 1,2, ZHOU Changren 1,2 |
1.Department of Materials Science and Engineering, Jinan University, Guangzhou 510632
2.Engineering Research Center of Artificial Organs and Materials, Ministry of Education, Jinan University, Guangzhou 510632 |
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Cite this article:
LUO Binghong CHENG Song ZHONG Cuihong JIAO Yanpeng ZHOU Changren. Synthesis of CS--g--PDLLA Copolymer and {\it in-situ} Fabrication of CS--g--PDLLA/PDLLA Porous Scaffolds in Supercritical Carbon Dioxide. Chin J Mater Res, 2010, 24(3): 225-231.
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Abstract Poly(D,L-lactide) (PDLLA) and chitosan--graft--poly(D,L-lactide) (CS--g--PDLLA) copolymer were synthesized firstly in supercritical carbon dioxide (scCO2) using D,L-lactide and chitosan as raw materials and tin (II) 2--ethylhexanoate as catalyst. Then, CS--g--PDLLA/PDLLA porous scaffolds were prepared in-situ by scCO2 extraction/pore forming technologies. The structure and properties of the graft copolymers and the molecular weight of PDLLA were characterized. The porous structure morphology of the scaffolds was observed and the porosity of the scaffolds was measured. The results showed that PDLLA and CS--g--PDLLA were synthesised successfully in scCO2 fluid, and the structure of the graft copolymer, the molecular weight and yield of PDLLA can be adjusted by controlling the feeding ratio, reaction temperature and time. Uniformly distributed and highly interconnected pore structures with a unique long gully type microstructure were formed in the CS--g--PDLLA/PDLLA scaffolds, and the compatibility of CS--g--PDLLA with PDLLA was good. Moreover, the depressurization rate and temperature have effects on the structure morphology of the porous scaffolds.
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Received: 01 February 2010
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| Fund: Supported by National Natural Science Foundation of China No.30500128, National Hi-Tech Research and Development Program of China No.2007AA091603, and Sci--Tech Innovation Foundation of the "211 Project" for Biomaterials and Tissue Engineering, Jinan University No.50621030. |
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