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| Synthesis and Drug Release Performance of Chitosan Immobilized Cyclodextrin–Sodium Alginate |
| HONG Chunshuang, LI Mingchun, XIN Meihua, XIE Feng, MAO Yangfan |
| College of Material Science and Engineering, Huaqiao University, The Key Laboratory for Functional Materials of Fujian Higher Education, Xiamen 361021 |
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Cite this article:
HONG Chunshuang LI Mingchun XIN Meihua XIE Feng MAO Yangfan. Synthesis and Drug Release Performance of Chitosan Immobilized Cyclodextrin–Sodium Alginate. Chin J Mater Res, 2011, 25(2): 135-140.
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Abstract An acid soluble chitosan immobilized cyclodextrin (CDS) was synthesized by grafting p–toluenesulfonyl–β–cyclodextrin onto chitosan, then formed gel with alginate sodium (ALg–CDS). The structure of ALg–CDS was characterized by FTIR, UV, TG–DTA, XRD and SEM, and using ketoprofen as a modal drug, the release behavior from ALg–CDS and ALg–CS in simulated intestinal fluid and simulated gastric fluid had been investigated. The results show that the swelling ratio of ALg–CDS in simulated intestinal fluid was higher than that in simulated gastric fluid. ALg–CDS (4.19 mg/mg) has better drug–loading capacity than that of ALg–CS (3.76 mg/mg), and represented more stable release of the entrapped ketoprofen in simulated intestinal fluid because of cyclodextrin, the adsorption data was in line with the Lagergren second–order kinetics.
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Received: 12 November 2010
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| Fund: Supported by the Key Projection of Science and Technology of Fujian Province No.2009H0030, the Provincial Natural Science Foundation of Fujian Nos.0810019 & 2009J01029, and the Scientists–Company Copperation Project of the Ministry of Science and Technology of China. |
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