In order to study the deformation behavior of a directionally solidified nickel based high-temperature alloy DZ411 by cyclic loads (20-380 MPa) at temperatures (1173-1223 K) was studied via electronic creep testing machine, optical microscopy and electron field emission scanning electron microscopy etc. Meanwhile a model of the fracture life of the alloy was also established and compared with the test results. The results show that under constant and cyclic loads, the fracture life (t_r) and minimum strain rate ({\dot{\epsilon }}_{\mathrm{m}\mathrm{i}\mathrm{n}}) of the alloy both conform to the Monkman-Grant equation and can be fitted well on the same data set. As the test temperature, stress amplitude, and average stress decrease, the fracture time increases and the internal damage of the alloy intensifies. The minimum strain rate and average stress of the alloy follow a power-law relationship, but considering the comprehensive effect of the average stress (σ_m) and stress amplitude (σ_a) on the fracture life in cyclic testing, the equivalent stress may be corrected according to ({\sigma }_{\mathrm{e}\mathrm{q}}={\sigma }_{\mathrm{m}}^{\gamma }{\sigma }_{\mathrm{m}\mathrm{a}\mathrm{x}}^{\mathrm{1}-\gamma }, γ = 0.1), and the Larson-Miller parameter method (P\left({\sigma }_{\mathrm{e}\mathrm{q}}\right)=T\left[C+\mathrm{l}\mathrm{g}\left(t_{\mathrm{r}}\right)\right]) is used to normalize the fracture life by different loading conditions, thus achieving life prediction by various temperature and loading conditions.