Preparation and Properties of 3D Porous Novel Biodegradable Polyurethane Scaffolds

Chinese Journal of Materials Research

2013, Vol. 27

Issue (4): 391-396 DOI:

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Preparation and Properties of 3D Porous Novel Biodegradable Polyurethane Scaffolds

HE Xianyun^1** QIU Yongliang¹ WANG Yingjun^{2, 3} WU Gang^{2, 3}

1. Department of mechanical engineering, Guangdong College of industry and commerce, Guangzhou 510510
2. School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641
3. National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou 510006

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HE Xianyun** QIU Yongliang WANG Yingjun,WU Gang,. Preparation and Properties of 3D Porous Novel Biodegradable Polyurethane Scaffolds. Chinese Journal of Materials Research, 2013, 27(4): 391-396.

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Abstract A two-step method was used to synthesize a novel biodegradable polyurethane (PU) composed by L-lysine ethyl ester diisocyanate (LDI), poly (ε-caprolactone) diols (PCL-diol) and 1, 4: 3, 6-dianhydro-D-sorbitol (Isosorbide) as chain extender. 3D porous PU scaffolds were produced by a combined salt leaching-phase inverse technique. The surface structure, pore size, pore size distribution, pore interconnectivity and mechanical properties of the scaffolds were investigated. The bio-safety of PU was evaluated with cell proliferation of mouse ATDC5. Results show that micorpores and macropores distributed in the produced scaffolds with high porosity (more than 75%). The scaffolds that were prepared with addition of methanol and water have good tensile strength, with well interconnected pores. In addition, the CCK-8 expriment result displayed that the cells could survive and proliferate on PU scaffolds.

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