材料研究学报  2004, Vol. 18 Issue (4): 380-384

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冠脉支架表面载药涂层的制备和性能

谭丽丽;薛松;杨柯;张炳春;刘冬雪;梁勇

中国科学院金属研究所

Preparation and properties of drug elusion coating on coronary stents

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中国科学院金属研究所

谭丽丽; 薛松; 杨柯; 张炳春; 刘冬雪; 梁勇 . 冠脉支架表面载药涂层的制备和性能[J]. 材料研究学报, 2004, 18(4): 380-384.
, , , , , . Preparation and properties of drug elusion coating on coronary stents[J]. Chin J Mater Res, 2004, 18(4): 380-384.

摘要 参考文献 相关文章 Metrics 全文: PDF(1255 KB)   摘要: 采用溶液聚合法制备了改性的聚甲基丙烯酸树脂, 作为支架表面载药涂层的药物载体聚合物. 采用浸涂法制备了不锈钢基体表面聚合物及聚合物载药涂层, 并利用红外光谱及核磁共振波谱分析了所制备共聚物的成分, 并评价了物理性能、 生物稳定性能以及药物的释放性能. 结果表明, 所制备的涂层具有较好的生物稳定性, 甲基丙烯酸和甲基丙烯酸丁酯的加入提高了聚合物的物理性能, 尤其是涂层与金属基体的结合力. 所制备的药物释放涂层具有缓释紫杉醇的功能, 其释放周期超过15 d. 聚甲基丙烯酸树脂携带紫杉醇的载药涂层在生物稳定性、 物理性能及药物释放性能方面满足冠脉支架的表面涂层的使用要求. 关键词 ： 聚合物材料,  冠脉支架,  载药涂层,  制备及性能     Abstract：Solution polymerisation was employed to prepare the modified polymethacrylate resin as the polymer for coating on coronary stents with drug elusion. Both the polymer and the drug elusion coatings on the stainless steel were prepared by the dipping technology. The composition of copolymer was analyzed by IR and NMR techniques, and the physical property, the biostability and the drug elusion characteristic were also evaluated by Ultro--spectrophotometer, HPLC. The results show that the modified polymethacrylate resin has favorable biostability, and the addition of MAA and BMA provides the polymer with improved physical property, especially the adhesive force between the polymer coating and the stainless steel substrate. The drug elusion coating has paclitaxol releasing function, and its releasing time is more than 15 days. The manufactured paclitaxol--releasing polymethacrylate resin coating can be used as the coronary stent coating. Key words： polymer materials    coronary stent    drug elusion coating    preparation and property 收稿日期: 2004-08-31      ZTFLH:  TB324   服务 把本文推荐给朋友 加入引用管理器 E-mail Alert RSS 作者相关文章 谭丽丽 薛松 杨柯 张炳春 刘冬雪 梁勇 44.8K 链接本文: https://www.cjmr.org/CN/      或      https://www.cjmr.org/CN/Y2004/V18/I4/380 1 Yoon Ki Joung, Hyun Il Kim, Sung Soo Kim, Kwang Hoe Chung, Yang Soo Jang, Ki Dong Park, Journal of Controlled Release, 92, 83(2003) 2 Samer M. Garas, Philip Huber, Neal A. Scott, Pharmacology & Therapeutics, 92, 165(2001) 3 A.L.Lewis, L.A.Tolhurst, P.W.Stratford, Biomaterials, 23(7) , 1697(2002) 4 Neil Swanson, Kai Hogrefe, Qamar Javed, Anthony H. Gershlick, International Journal of Cardiology, 92(2-3) , 247(2003) 5 FENG Zhaoxuan, QI Guorong, Macromolecule material in medicine. (Hangzhou, Zhejiang University Press, 1989) p.125(风兆玄,戚国荣,医用高分子(杭州,浙江大学出版社,1989) p.l25) 6 H.J.Long, Mayo Clin Proc., 69, 341(1994) 7 HAO Heping, Guide to the Biological Evaluation Standard of Medical Equipments (Beijing, Chinese Standard Press, 2000) p.155(郝和平,医疗器械生物学评价标准实施指南(北京,中国标准出版社,2000) p.155) 8 A.W.Clowes, M.A.Reidy, M.M.Clowes, Lab. Invest., 49, 327(1983) 9 A.W.Clowes, M.A.Reidy, M.M.Clowes, Lab. Invest., 49, 208(1983) [1] 毛志刚 谭丽丽 郑丰 黄洁雯 樊新民 杨柯. 无镍不锈钢冠脉支架力学行为的有限元模拟[J]. 材料研究学报, 2012, 26(2): 125-131. [2] 李绮 汤岩 谭丽丽 颜廷亭 张炳春 杨柯. 可降解镁合金表面载药涂层的制备和性能[J]. 材料研究学报, 2009, 23(3): 300-304. [3] 宋名实. 高分子材料的极限断裂强度和破坏性能的研究——Ⅱ.蠕变持久强度的动力学模型理论[J]. 材料研究学报, 1990, 4(1): 91-96. Viewed Full text Abstract Cited   Shared      Discussed