The creep property of 4 nickel-based single crystal superalloys with 4% W, 6% W and 6%W+2%Ru is comparatively studied by creep testing machine, scanning electron microscope, three dimensional atom probe and X-ray diffractometer, aiming to clarify the effect of Ru on the creep performance of the alloy. The results show that the increase in W content will impair the creep performance of the alloy, the creep life of the alloy with 6%W decreases to 58 h at 1070℃/137 MPa. The alloying with Ru can promote the distribution of element W in γ/γ phase more reasonably, whilst inhibit the diffusion of element W from γ phase to γ phase during high temperature creep testing. Therefore, the alloy with 6%W+2%Ru presents a high creep life of 383 h at 1070℃/137 MPa, while no TCP precipitate in the alloy may be observed after high temperature creep testing. During the high temperature creep of the three alloys, the γ phase can form perpendicular to the direction of stress axis, and the TCP phase can destroy the continuity of the raft-like structure, resulting in the increase of the kinking degree of γ/γ phases, which is the main reason for the low creep life of the Ru-free 6%W alloy.